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Tooth decay, also known as caries,The word 'caries' is a mass noun, and is not a plural of 'carie'. is the breakdown of teeth due to acids produced by bacteria. The resulting cavities may be many different colors, from yellow to black. Symptoms may include pain and difficulty eating. Complications may include inflammation of the tissue around the tooth, tooth loss and infection or dental abscess formation. Tooth regeneration is an ongoing stem cell–based field of study that aims to find methods to reverse the effects of decay; current methods are based on easing symptoms.
The cause of cavities is acid from bacteria dissolving the of the teeth (Tooth enamel, dentin, and cementum). The acid is produced by the bacteria when they break down food debris or sugar on the tooth surface. in food are these bacteria's primary energy source, and thus a diet high in simple sugar is a risk factor. If mineral breakdown is greater than buildup from sources such as saliva, caries results. Risk factors include conditions that result in less saliva, such as diabetes mellitus, Sjögren syndrome, and some medications. Medications that decrease saliva production include psychostimulants, antihistamines, and . Dental caries are also associated with poverty, poor oral hygiene, and receding gums resulting in exposure of the roots of the teeth.
Prevention of dental caries includes regular cleaning of the teeth, a diet low in sugar, and small amounts of fluoride. Brushing one's teeth twice per day, and flossing between the teeth once a day is recommended. Fluoride may be acquired from water, salt or toothpaste among other sources. Treating a mother's dental caries may decrease the risk in her children by decreasing the number of certain bacteria she may spread to them. Screening can result in earlier detection. Depending on the extent of destruction, various treatments can be used to restore the tooth to proper function, or the tooth may be removed. There is no known method to grow back large amounts of tooth. The availability of treatment is often poor in the developing world. Paracetamol (acetaminophen) or ibuprofen may be taken for pain.
Worldwide, approximately 3.6 billion people (48% of the population) have dental caries in their permanent teeth as of 2016. The World Health Organization estimates that nearly all adults have dental caries at some point in time. In baby teeth it affects about 620 million people or 9% of the population. They have become more common in both children and adults in recent years. The disease is most common in the developed world due to greater simple sugar consumption, but less common in the developing world. Caries is Latin for "rottenness".
As the lesion continues to demineralize, it can turn brown but will eventually turn into a cavitation ("cavity"). A lesion that appears dark brown and shiny suggests dental caries were once present, but the demineralization process has stopped, leaving a stain. Active decay is lighter in color and appears dull.Johnson, Clarke. " Biology of the Human Dentition ." Page accessed July 18, 2007.
As the Enamel organ and dentin are destroyed, the cavity becomes more noticeable. The affected areas of the tooth change color and become soft to the touch. Once the decay passes through the enamel, the dentinal tubules, which have passages to the nerve of the tooth, become exposed, resulting in pain that can be transient, temporarily worsening with exposure to heat, cold, or sweet foods and drinks. A tooth weakened by extensive internal decay can sometimes suddenly Bone fracture under normal chewing forces. When the decay has progressed enough to allow the bacteria to overwhelm the pulp tissue in the center of the tooth, a toothache can result, and the pain will become more constant. Death of the pulp tissue and infection are common consequences. The tooth will no longer be sensitive to hot or cold, but can be quite tender to pressure.
Dental caries can also cause halitosis and foul tastes. Tooth Decay, hosted on the New York University Medical Center website. Page accessed August 14, 2006. In highly progressed cases, an infection can spread from the tooth to the surrounding . Complications such as cavernous sinus thrombosis and Ludwig angina can be life-threatening. Cavernous Sinus Thrombosis , hosted on WebMD. Page accessed May 25, 2008.Hartmann, Richard W. Ludwig's Angina in Children , hosted on the American Academy of Family Physicians website. Page accessed May 25, 2008.
Tooth decay is caused by biofilm (dental plaque) lying on the teeth and maturing to become cariogenic (causing decay). Certain bacteria in the biofilm produce acids, primarily lactic acid, in the presence of fermentable carbohydrates such as sucrose, fructose, and glucose.
Caries occur more in people from the lower end of the socioeconomic scale than in people from a higher socioeconomic background. This is due to a lack of education about dental care and poor access to professional dental care, which may be expensive.Watt RG, Listl S, Peres MA, Heilmann A, editors. Social inequalities in oral health: from evidence to action . London: International Centre for Oral Health Inequalities Research & Policy; www.icohirp.com
The mouth contains a wide variety of oral ecology. Only a few specific species of bacteria are believed to cause dental caries: Streptococcus mutans and Lactobacillus species among them. Streptococcus mutans are gram-positive bacteria that constitute biofilms on the surface of teeth. These organisms can produce high levels of lactic acid following fermentation of dietary sugars and are resistant to the adverse effects of low pH, properties essential for cariogenic bacteria. As the cementum of root surfaces is more easily demineralized than enamel surfaces, a wider variety of bacteria can cause root caries, including Lactobacillus acidophilus, Actinomyces, Nocardia spp., and Streptococcus mutans. Bacteria collect around the teeth and gums in a sticky, creamy-coloured mass called dental plaque, which serves as a biofilm. Some sites collect plaque more commonly than others, for example, sites with a low rate of salivary flow (molar fissures). Grooves on the occlusal surfaces of molar and premolar teeth provide microscopic retention sites for plaque bacteria, as do the interproximal sites. Plaque may also collect above or below the gingiva, where it is referred to as supra- or sub-gingival plaque, respectively.
These bacterial strains, most notably S. mutans, can be inherited by a child from a caretaker's kiss or through feeding premastication food.
The carious process can begin within days of a tooth's erupting into the mouth if the diet is sufficiently rich in suitable carbohydrates. Evidence suggests that the introduction of fluoride treatments has slowed the process.Summit, James B., J. William Robbins, and Richard S. Schwartz. "" 2nd edition. Carol Stream, Illinois, Quintessence Publishing Co, Inc, 2001, p. 75. . Proximal caries take an average of four years to pass through enamel in permanent teeth. Because the cementum enveloping the root surface is not nearly as durable as the enamel encasing the crown, root caries tend to progress much more rapidly than decay on other surfaces. The progression and loss of mineralization on the root surface is 2.5 times faster than caries in enamel. In very severe cases where oral hygiene is very poor and where the diet is very rich in fermentable carbohydrates, caries may cause cavities within months of tooth eruption. This can occur, for example, when children continuously drink sugary drinks from baby bottles (see later discussion).
Molar incisor hypo-mineralization seems to be increasingly common. While the cause is unknown it is thought to be a combination of genetic and environmental factors. Possible contributing factors that have been investigated include systemic factors such as high levels of dioxins or polychlorinated biphenyl (PCB) in the mother's milk, preterm birth and oxygen deprivation at birth, and certain disorders during the child's first 3 years such as mumps, diphtheria, scarlet fever, measles, hypoparathyroidism, malnutrition, malabsorption, hypo-vitaminosis D, chronic respiratory diseases, or undiagnosed and untreated coeliac disease, which usually presents with mild or absent gastrointestinal symptoms.
Amelogenesis imperfecta, which occurs in between 1 in 718 and 1 in 14,000 individuals, is a disease in which the enamel does not fully form or forms in insufficient amounts and can fall off a tooth.Neville, B.W., Damm, Douglas; Allen, Carl and Bouquot, Jerry (2002). " Oral & Maxillofacial Pathology." 2nd edition, p. 89. . In both cases, teeth may be left more vulnerable to decay because the enamel is not able to protect the tooth.Neville, B.W., Damm, Douglas; Allen, Carl and Bouquot, Jerry (2002). " Oral & Maxillofacial Pathology." 2nd edition, p. 94. .
In most people, disorders or diseases affecting teeth are not the primary cause of dental caries. Approximately 96% of tooth enamel is composed of minerals.Nanci, p. 122 These minerals, especially hydroxyapatite, will become soluble when exposed to acidic environments. Enamel begins to demineralize at a pH of 5.5. Dentin and cementum are more susceptible to caries than Tooth enamel because they have lower mineral content. Thus, when root surfaces of teeth are exposed from gingival recession or periodontal disease, caries can develop more readily. Even in a healthy oral environment, however, the tooth is susceptible to dental caries.
The evidence for linking malocclusion and/or crowding to dental caries is weak; however, the anatomy of teeth may affect the likelihood of caries formation. Where the deep developmental grooves of teeth are more numerous and exaggerated, pit and fissure caries is more likely to develop (see next section). Also, caries is more likely to develop when food is trapped between teeth.
Stimulants, most notoriously methylamphetamine, also occlude the flow of saliva to an extreme degree. This is known as meth mouth. Tetrahydrocannabinol (THC), the active chemical substance in cannabis, also causes a nearly complete occlusion of salivation, known in colloquial terms as "cotton mouth". Moreover, 63% of the most commonly prescribed medications in the United States list dry mouth as a known side effect. Radiation therapy of the head and neck may also damage the cells in salivary glands, somewhat increasing the likelihood of caries formation. Oral Complications of Chemotherapy and Head/Neck Radiation , hosted on the National Cancer Institute website. Page accessed January 8, 2007.See Common effects of cancer therapies on salivary glands at
Susceptibility to caries can be related to altered metabolism in the tooth, in particular to fluid flow in the dentin. Experiments on rats have shown that a high-sucrose, cariogenic diet "significantly suppresses the rate of fluid motion" in dentin.Ralph R. Steinman & John Leonora (1971) "Relationship of fluid transport through dentation to the incidence of dental caries", Journal of Dental Research 50(6): 1536 to 43
The use of tobacco may also increase the risk for caries formation. Some brands of dipping tobacco contain high sugar content, increasing susceptibility to caries.Neville, B.W., Douglas Damm, Carl Allen, Jerry Bouquot. Oral & Maxillofacial Pathology 2nd edition, 2002, p. 347. . Tobacco use is a significant risk factor for periodontal disease, which can cause the gingiva to receding gums. Tobacco Use Increases the Risk of Gum Disease , hosted on the American Academy of Periodontology . Page accessed January 9, 2007. As the gingiva loses attachment to the teeth due to gingival recession, the root surface becomes more visible in the mouth. If this occurs, root caries is a concern since the cementum covering the roots of teeth is more easily demineralized by acids than enamel.Banting, D. W. " The Diagnosis of Root Caries ." Presentation to the National Institute of Health Consensus Development Conference on Diagnosis and Management of Dental Caries Throughout Life, in pdf format, hosted on the National Institute of Dental and Craniofacial Research, p. 19. Page accessed August 15, 2006. Currently, there is not enough evidence to support a causal relationship between smoking and coronal caries, but evidence does suggest a relationship between smoking and root-surface caries. Executive Summary of U.S. Surgeon General's report titled, "The Health Consequences of Smoking: A Report of the Surgeon General," hosted on the CDC website, p. 12. Page accessed January 9, 2007.
Exposure of children to passive smoking is associated with tooth decay.
Intrauterine and neonatal lead exposure promote tooth decay. Besides lead, all atoms with electrical charge and ionic radius similar to bivalent calcium,
such as cadmium, mimic the calcium ion, and therefore exposure to them may promote tooth decay.
Poverty is also a significant social determinant for oral health. Dental caries have been linked with lower socio-economic status and can be considered a disease of poverty.
Forms are available for risk assessment for caries when treating dental cases; this system uses the evidence-based CAMBRA (CAMBRA). ADA Caries Risk Assessment Form Completion Instructions. American Dental Association It is unknown if the identification of high-risk individuals leads to more effective long-term patient management that prevents caries initiation and arrests or reverses the progression of lesions.
Saliva also contains iodine and EGF. EGF results are effective in cellular proliferation, differentiation, and survival. Salivary EGF, which seems also regulated by dietary inorganic iodine, plays an important physiological role in the maintenance of oral (and gastro-oesophageal) tissue integrity, and, on the other hand, iodine is effective in the prevention of dental caries and oral health.
The minerals in the hard tissues of the teeth enamel, dentin, and cementum are constantly undergoing demineralization and remineralization. Dental caries result when the demineralization rate is faster than the remineralization, producing net mineral loss, which occurs when there is an ecologic shift within the dental biofilm from a balanced population of microorganisms to a population that produces acids and can survive in an acid environment.Fejerskov O, Nyvad B, Kidd EA (2008) "Pathology of dental caries", pp 20–48 in Fejerskov O, Kidd EAM (eds) Dental caries: The disease and its clinical management. Oxford, Blackwell Munksgaard, Vol. 2. .
As the enamel loses minerals, and dental caries progresses, the enamel develops several distinct zones, visible under a light microscope. From the deepest layer of the enamel to the enamel surface, the identified areas are the translucent zone, dark zones, body of the lesion, and surface zone. The translucent zone is the first visible sign of caries and coincides with a one to two percent loss of minerals. A slight remineralization of enamel occurs in the dark zone, which serves as an example of how the development of dental caries is an active process with alternating changes.Nanci, p. 121 The area of greatest demineralization and destruction is in the body of the lesion itself. The surface zone remains relatively mineralized until the loss of tooth structure results in a cavitation.
In dentin, from the deepest layer to the enamel, the distinct areas affected by caries are the advancing front, the zone of bacterial penetration, and the zone of destruction. The advancing front represents a zone of demineralized dentin due to acid and has no bacteria present. The zones of bacterial penetration and destruction are the locations of invading bacteria and ultimately the decomposition of dentin. The zone of destruction has a more mixed bacterial population where proteolytic enzymes have destroyed the organic matrix. The innermost dentin caries has been reversibly attacked because the collagen matrix is not severely damaged, giving it potential for repair.
In response, the fluid inside the tubules brings from the immune system to fight the bacterial infection. At the same time, there is an increase in mineralization of the surrounding tubules.Summit, James B., J. William Robbins, and Richard S. Schwartz. Fundamentals of Operative Dentistry: A Contemporary Approach 2nd edition. Carol Stream, Illinois, Quintessence Publishing Co, Inc, 2001, p. 13. . This results in a constriction of the tubules, which is an attempt to slow the bacterial progression. In addition, as the acid from the bacteria demineralizes the hydroxyapatite crystals, calcium and phosphorus are released, allowing for the precipitation of more crystals which fall deeper into the dentinal tubule. These crystals form a barrier and slow the advancement of caries. After these protective responses, the dentin is considered sclerotic.
According to hydrodynamic theory, fluids within dentinal tubules are believed to be the mechanism by which pain receptors are triggered within the pulp of the tooth. Since sclerotic dentin prevents the passage of such fluids, pain that would otherwise serve as a warning of the invading bacteria may not develop at first.
In the case of reparative dentin, other cells are needed to assume the role of the destroyed odontoblasts. , especially TGF beta, are thought to initiate the production of reparative dentin by and mesenchymal cells of the pulp.Summit, James B., J. William Robbins, and Richard S. Schwartz. "Fundamentals of Operative Dentistry: A Contemporary Approach." 2nd edition. Carol Stream, Illinois, Quintessence Publishing Co, Inc, 2001, p. 14. . Reparative dentin is produced at an average of 1.5 μm/day, but can be increased to 3.5 μm/day. The resulting dentin contains irregularly shaped dentinal tubules that may not line up with existing dentinal tubules. This diminishes the ability for dental caries to progress within the dentinal tubules.
Primary diagnosis involves inspection of all visible tooth surfaces using a good light source, mouth mirror, and Dental explorer. Dental radiographs () may show dental caries before it is otherwise visible, in particular caries between the teeth. Large areas of dental caries are often apparent to the naked eye, but smaller lesions can be difficult to identify. Visual and Tactition inspection, along with radiographs, are employed frequently among dentists, in particular to diagnose pit and fissure caries.Rosenstiel, Stephen F. Clinical Diagnosis of Dental Caries: A North American Perspective . Maintained by the University of Michigan Dentistry Library, along with the National Institutes of Health, National Institute of Dental and Craniofacial Research. 2000. Page accessed August 13, 2006. Early, uncavitated caries is often diagnosed by blowing air across the suspect surface, which removes moisture and changes the optical properties of the unmineralized enamel.
Some dental researchers have cautioned against the use of dental explorers to find caries,Summit, James B., J. William Robbins, and Richard S. Schwartz. Fundamentals of Operative Dentistry: A Contemporary Approach 2nd edition. Carol Stream, Illinois, Quintessence Publishing Co, Inc, 2001, p. 31. . in particular sharp ended explorers. In cases where a small area of tooth has begun demineralizing but has not yet cavitated, the pressure from the dental explorer could cause a cavity. Since the carious process is reversible before a cavity is present, it may be possible to arrest caries with Fluoride therapy and remineralize the tooth surface. When a cavity is present, a restoration will be needed to replace the lost tooth structure.
At times, pit and fissure caries may be difficult to detect. Bacteria can penetrate the enamel to reach dentin, but then the outer surface may remineralize, especially if fluoride is present. These caries, sometimes referred to as "hidden caries", will still be visible on X-ray radiographs, but visual examination of the tooth would show the enamel intact or minimally perforated.
The differential diagnosis for dental caries includes dental fluorosis and developmental defects of the tooth including hypomineralization of the tooth and hypoplasia of the tooth.
The early carious lesion is characterized by demineralization of the tooth surface, altering the tooth's optical properties. Technology using Speckle pattern (LSI) techniques may provide a diagnostic aid to detect early carious lesions.
Another pattern of decay is "rampant caries", which signifies advanced or severe decay on multiple surfaces of many teeth. Radiographic Classification of Caries . Hosted on the Ohio State University website. Page accessed August 14, 2006. Rampant caries may be seen in individuals with xerostomia, poor oral hygiene, stimulant use (due to drug-induced dry mouth ADA Methamphetamine Use (METH MOUTH) . Hosted on the American Dental Association website. Page accessed February 14, 2007.), and/or large sugar intake. If rampant caries is a result of previous radiation to the head and neck, it may be described as radiation-induced caries. Problems can also be caused by the self-destruction of roots and whole root resorption when new teeth erupt or later from unknown causes.
Children between 6–12 months are at increased risk of developing dental caries.
A range of studies have reported a correlation between caries in primary teeth and caries in permanent teeth.
Recurrent caries, also known as secondary, are caries that appear at a location with a previous history of caries. This is frequently found on the margins of fillings and other dental restorations. On the other hand, incipient caries describes decay at a location that has not experienced previous decay. Arrested caries describes a lesion on a tooth that was previously demineralized but was remineralized before causing a cavitation. Fluoride therapy can help recalcification of tooth enamel, as well as the use of amorphous calcium phosphate.
Micro-invasive interventions (such as dental sealant or resin infiltration) have been shown to slow down the progression of proximal decay.
A toothbrush can be used to remove plaque on accessible surfaces, but not between teeth or inside pits and fissures on chewing surfaces. When used correctly, dental floss removes plaque from areas that could otherwise develop proximal caries, but only if the depth of Gingival sulcus has not been compromised. Additional aids include interdental brushes, , and . The use of rotational electric toothbrushes may reduce the risk of plaque and gingivitis, though it is unclear whether they are of clinical importance.
However, oral hygiene is effective at preventing gum disease (gingivitis / periodontal disease). Food is forced inside pits and fissures under chewing pressure, leading to carbohydrate-fuelled acid demineralisation where the brush, fluoride or hydroxyapatite toothpastes, and saliva have no access to remove trapped food, neutralise acid, or remineralise tooth enamel. (Occlusal caries accounts for between 80 and 90% of caries in children (Weintraub, 2001).) Unlike brushing, fluoride leads to a proven reduction in caries incidence by approximately 25%; higher concentrations of fluoride (>1,000 ppm) in toothpaste also help prevent tooth decay, with the effect increasing with concentration up to a plateau. A randomized clinical trial demonstrated that toothpastes that contain arginine have greater protection against tooth cavitation than the regular fluoride toothpastes containing 1450 ppm alone. A Cochrane review has confirmed that the use of fluoride gels, normally applied by a dental professional from once to several times a year, assists in the prevention of tooth decay in children and adolescents, reiterating the importance of fluoride as the principal means of caries prevention. Another review concluded that the supervised regular use of a fluoride mouthwash greatly reduced the onset of decay in the permanent teeth of children.
Professional hygiene care consists of regular dental examinations and professional prophylaxis (cleaning). Sometimes, complete plaque removal is difficult, and a dentist or dental hygienist may be needed. Along with oral hygiene, radiographs may be taken at dental visits to detect possible dental caries development in high-risk areas of the mouth (e.g., "bitewing" X-rays, which visualize the crowns of the back teeth).
Alternative methods of oral hygiene also exist around the world, such as the use of teeth cleaning twigs, such as in some Middle Eastern and African cultures. There is some limited evidence demonstrating the efficacy of these alternative methods of oral hygiene.
Chewy and sticky foods (such as candy, cookies, potato chips, and crackers) tend to adhere to teeth for longer periods. However, dried fruits such as raisins and fresh fruit such as apples and bananas disappear from the mouth quickly and do not appear to be a risk factor. Consumers are not good at assessing which foods remain in the mouth.
For children, the American Dental Association and the European Academy of Paediatric Dentistry recommend limiting the frequency of consumption of drinks with sugar, and not giving baby bottles to infants during sleep (see earlier discussion). Oral Health Topics: Baby Bottle Tooth Decay , hosted on the American Dental Association website. Page accessed August 14, 2006. Parents are also recommended to avoid sharing utensils and cups with their infants to prevent transferring bacteria from the parent's mouth. Guideline on Infant Oral Health Care , hosted on the American Academy of Pediatric Dentistry website. Page accessed January 13, 2007.
Xylitol is a naturally occurring sugar alcohol that is used in different products as an alternative to sucrose (table sugar). As of 2015, the evidence concerning the use of xylitol in chewing gum was insufficient to determine if it is effective at preventing caries.
Calcium, as found in food such as milk and green vegetables, is often recommended to protect against dental caries. Fluoride helps prevent decay of a tooth by binding to the hydroxyapatite crystals in enamel.Nanci, p. 7 Streptococcus mutans is the leading cause of tooth decay. Low-concentration fluoride ions act as a bacteriostatic therapeutic agent. High-concentration fluoride ions are bactericidal. The incorporated fluorine makes enamel more resistant to demineralization and, thus, resistant to decay.Ross, Michael H., Kaye, Gordon I. and Pawlina, Wojciech (2003). Histology: A Text and Atlas. 4th edition, p. 453. . Fluoride can be found in either topical or systemic form. Topical fluoride is more highly recommended than systemic intake to protect the surface of the teeth.Limited evidence suggests fluoride varnish applied twice yearly is effective for caries prevention in children at Topical fluoride is used in toothpaste, mouthwash and fluoride varnish. Standard fluoride toothpaste (1,000–1,500 ppm) is more effective than low fluoride toothpaste (< 600ppm) to prevent dental caries.
It is recommended that all adult patients use fluoridated toothpaste with at least 1350ppm fluoride content, brushing at least 2 times per day, and brushing right before bed. For children and young adults, use fluoridated toothpaste with 1350ppm to 1500ppm fluoride content, brushing 2 times per day, and also brushing right before bed. The American Dental Association Council recommends that for children under 3 years old, caregivers should begin brushing their teeth by using fluoridated toothpaste with an amount no more than a smear. Supervised toothbrushing must also be done for children below 8 years of age to prevent swallowing of toothpaste. After brushing with fluoride toothpaste, rinsing should be avoided and the excess spat out. Many dental professionals include application of topical fluoride solutions as part of routine visits and recommend the use of xylitol and amorphous calcium phosphate products.
Silver diammine fluoride may work better than fluoride varnish to prevent cavities. Systemic fluoride is found as lozenges, tablets, drops and water fluoridation. These are ingested orally to provide fluoride systemically.
Water fluoridation is beneficial in preventing tooth decay, especially in low socioeconomic areas, where other forms of fluoride are not available. However, a Cochrane systematic review found no evidence to suggest that taking fluoride systemically daily in pregnant women was effective in preventing dental decay in their offspring.
While some products containing chlorhexidine have been shown to limit the progression of existing tooth decay, there is currently no evidence suggesting that chlorhexidine gels and varnishes can prevent dental caries or reduce the population of Streptococcus mutans in the mouth.
An oral health assessment performed before a child reaches the age of one may help with the management of caries. The oral health assessment should include checking the child's history, a clinical examination, checking the risk of caries in the child including the state of their occlusion and assessing how well equipped the child's parent or carer is to help the child prevent caries. To increase a child's cooperation in caries management further, good communication by the dentist and the rest of the staff of a dental practice should be used. This communication can be improved by calling the child by their name, maintaining eye contact, and including them in any conversation about their treatment.
Caries vaccine are also under development.
Most importantly, whether the carious lesion is cavitated or non-cavitated dictates the management. Clinical assessment of whether the lesion is active or arrested is also important. Noncavitated lesions can be stopped, and remineralization can occur under the right conditions. However, this may require extensive changes to the diet (reduction in frequency of refined sugars), improved oral hygiene (toothbrushing twice per day with fluoride toothpaste and daily flossing), and regular application of topical fluoride. More recently, Immunoglobulin Y specific to Streptococcus mutans has been used to suppress growth of S. mutans. Such management of a carious lesion is termed "non-operative" since no drilling is carried out on the tooth. Non-operative treatment requires excellent understanding and motivation from the individual; otherwise, the decay will continue.
Once a lesion has cavitated, especially if dentin is involved, remineralization is much more difficult, and a dental restoration is usually indicated ("operative treatment"). Before a restoration can be placed, all of the decay must be removed; otherwise, it will continue to progress underneath the filling. Sometimes, a small amount of decay can be left if it is entombed and there is a seal that isolates the bacteria from their substrate. This can be likened to placing a glass container over a candle, which burns itself out once the oxygen is used up. Techniques such as pulp capping are designed to avoid exposure of the dental pulp and overall reduction of the amount of tooth substance that requires removal before the final filling is placed. Often, enamel, which overlies decayed dentin, must also be removed as it is unsupported and susceptible to fracture. The modern decision-making process with regards the activity of the lesion, and whether it is cavitated, is summarized in the table.
Destroyed tooth structure does not fully regenerate, although remineralization of very small carious lesions may occur if dental hygiene is kept at an optimal level. For the small lesions, topical fluoride is sometimes used to encourage remineralization. For larger lesions, the progression of dental caries can be stopped by treatment. The goal of treatment is to preserve tooth structures and prevent further destruction of the tooth. Aggressive treatment, by filling, of incipient carious lesions, places where there is superficial damage to the enamel, is controversial as they may heal themselves, while once a filling is performed, it will eventually have to be redone, and the site serves as a vulnerable site for further decay.
In general, early treatment is quicker and less expensive than treatment of extensive decay. , nitrous oxide ("laughing gas"), or other prescription medications may be required in some cases to relieve pain during or following treatment or to relieve anxiety during treatment. Oral Health Topics: Anesthesia Frequently Asked Questions , hosted on the American Dental Association website. Page accessed August 16, 2006. A dental drill ("drill") is used to remove large portions of decayed material from a tooth. A spoon, a dental instrument used to carefully remove decay, is sometimes employed when the decay in dentin reaches near the pulp.Summit, James B., J. William Robbins, and Richard S. Schwartz. "Fundamentals of Operative Dentistry: A Contemporary Approach." 2nd edition. Carol Stream, Illinois, Quintessence Publishing Co, Inc, 2001, p. 128. . Some dentists remove dental caries using a laser rather than the traditional dental drill. A Cochrane review of this technique looked at Er:YAG (erbium-doped yttrium aluminium garnet), Er,Cr:YSGG (erbium, chromium: yttrium-scandium-gallium-garnet) and Nd:YAG (neodymium-doped yttrium aluminium garnet) lasers and found that although people treated with lasers (compared to a conventional dental "drill") experienced less pain and had a lesser need for dental anaesthesia, that overall there was little difference in caries removal. Another alternative to drilling or lasers for small caries is the use of air abrasion, in which small abrasive particles are blasted at decay using pressurized air (similar to sand blasting). Once the decay is removed, the missing tooth structure requires a dental restoration of some sort to return the tooth to function and aesthetic condition.
Restorative materials include dental amalgam, dental composite resin, glass ionomer cement, dental porcelain, and gold." Aspects of Treatment of Cavities and of Caries Disease " from the Disease Control Priorities Project. Page accessed August 15, 2006. Composite resin and porcelain can be made to match the color of a patient's natural teeth and are thus used more frequently when aesthetics are a concern. Composite restorations are not as strong as dental amalgam and gold; some dentists consider the latter as the only advisable restoration for posterior areas where chewing forces are great. Oral Health Topics: Dental Filling Options , hosted on the American Dental Association website. Page accessed August 16, 2006. When the decay is too extensive, there may not be enough tooth structure remaining to allow a restorative material to be placed within the tooth. Thus, a crown may be needed. This restoration resembles a cap and is fitted over the remaining natural crown of the tooth. Crowns are often made of gold, porcelain, or porcelain fused to metal.
For children, preformed crowns are available to place over the tooth. These are usually made of metal (usually stainless steel, but increasingly there are aesthetic materials). Traditionally, teeth are shaved down to make room for the crown, but more recently, stainless steel crowns have been used to seal decay into the tooth and stop it from progressing. This is known as the Hall Technique and works by depriving the bacteria in the decay of nutrients and making their environment less favorable for them. It is a minimally invasive method of managing decay in children and does not require local anesthetic injections in the mouth.
In certain cases, endodontic therapy may be necessary for the restoration of a tooth. What is a Root Canal? , hosted by the Academy of General Dentistry. Page accessed August 16, 2006. Endodontic therapy, also known as a "root canal", is recommended if the pulp in a tooth dies from infection by decay-causing bacteria or from trauma. In root canal therapy, the pulp of the tooth, including the nerve and vascular tissues, is removed along with decayed portions of the tooth. The canals are instrumented with endodontic files to clean and shape them, and they are then usually filled with a rubber-like material called gutta percha. FAQs About Root Canal Treatment , hosted by the American Association of Endodontists website. Page accessed August 16, 2006. The tooth is filled, and a crown can be placed. Upon completion of root canal therapy, the tooth is non-vital, as it is devoid of any living tissue.
An extraction can also serve as treatment for dental caries. The removal of the decayed tooth is performed if the tooth is too severely damaged from the decay process to be effectively restored. Extractions are sometimes considered if the tooth lacks an opposing tooth or will probably cause further problems in the future, as may be the case for wisdom teeth. Wisdom Teeth , a packet in pdf format hosted by the American Association of Oral and Maxillofacial Surgeons. Page accessed August 16, 2006. Extractions may also be preferred by people unable or unwilling to undergo the expense or difficulties in restoring the tooth.
Recent studies from the University of Michigan demonstrated that silver diamine fluoride (SDF) is effective in stopping tooth decay when applied to the teeth of young children. The silver ions in SDF denature bacterial proteins and enzymes, effectively killing cariogenic bacteria such as Streptococcus mutans.
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Worldwide, approximately 3.6 billion people have dental caries in their permanent teeth. In baby teeth it affects about 620 million people or 9% of the population. The disease is most common in Latin American countries, countries in the Middle East, and South Asia, and least prevalent in China. The World Oral Health Report 2003: Continuous improvement of oral health in the 21st century – the approach of the WHO Global Oral Health Programme , released by the World Health Organization. (File in pdf format.) Page accessed August 15, 2006. In the United States, dental caries is the most common chronic childhood disease, being at least five times more common than asthma. Healthy People: 2010 . Html version hosted on Healthy People.gov website. Page accessed August 13, 2006. It is the primary pathological cause of tooth loss in children. Frequently Asked Questions , hosted on the American Dental Hygiene Association website. Page accessed August 15, 2006. Between 29% and 59% of adults over the age of 50 experience caries." Dental caries ", from the Disease Control Priorities Project. Page accessed August 15, 2006.
Treating dental cavities costs 5–10% of health-care budgets in industrialized countries, and can easily exceed budgets in lower-income countries.
The number of cases has decreased in some developed countries, and this decline is usually attributed to increasingly better oral hygiene practices and preventive measures such as fluoride treatment. World Health Organization website, "World Water Day 2001: Oral health", p. 2. Page accessed August 14, 2006. Nonetheless, countries that have experienced an overall decrease in cases of tooth decay continue to have a disparity in the distribution of the disease. Among children in the United States and Europe, twenty percent of the population endures sixty to eighty percent of cases of dental caries. A similarly skewed distribution of the disease is found throughout the world, with some children having none or very few caries and others having a high number. Australia, Nepal, and Sweden (where children receive dental care paid for by the government) have a low incidence of cases of dental caries among children, whereas cases are more numerous in Costa Rica and Slovakia." Table 38.1. Mean DMFT and SiC Index of 12-Year-Olds for Some Countries, by Ascending Order of DMFT ", from the Disease Control Priorities Project. Page accessed January 8, 2007.
The classic DMF (decay/missing/filled) index is one of the most common methods for assessing caries prevalence as well as dental treatment needs among populations. This index is based on in-field clinical examination of individuals by using a probe, mirror, and cotton rolls. Because the DMF index is done without X-ray imaging, it underestimates true caries prevalence and treatment needs.
Bacteria typically associated with dental caries have been isolated from vaginal samples from females who have bacterial vaginosis.
Archaeological evidence shows that tooth decay is an ancient disease dating far into prehistory. Human skull dating from a million years ago through the Neolithic period show signs of caries, including those from the Paleolithic and Mesolithic ages.Caries Through Time: An Anthropological Overview; Luis Pezo Lanfranco and Sabine Eggers; Laboratório de Antropologia Biológica, Depto. de Genética e Biologia Evolutiva, Instituto de Biociências, Universidade de São Paulo, Brazil The increase of caries during the Neolithic period may be attributed to the increased consumption of plant foods containing carbohydrates. The beginning of rice cultivation in South Asia is also believed to have caused an increase in caries especially for women, although there is also some evidence from sites in Thailand, such as Khok Phanom Di, that shows a decrease in overall percentage of dental caries with the increase in dependence on rice agriculture.
A Sumerian text from 5000 BC describes a "tooth worm" as the cause of caries. History of Dentistry: Ancient Origins , hosted on the American Dental Association website. Page accessed January 9, 2007. Evidence of this belief has also been found in India, Egypt, Japan, and China. Unearthed ancient skulls show evidence of primitive dental work. In Pakistan, teeth dating from around 5500 BC to 7000 BC show nearly perfect holes from primitive . The Ebers Papyrus, an text from 1550 BC, mentions diseases of teeth. During the Sargonid dynasty of Assyria during 668 to 626 BC, writings from the king's physician specify the need to extract a tooth due to spreading inflammation. In the Roman Empire, wider consumption of cooked foods led to a small increase in caries prevalence. The Greco-Roman civilization, in addition to the Egyptian civilization, had treatments for pain resulting from caries.
The rate of caries remained low through the Bronze Age and Iron Age, but sharply increased during the Middle Ages. Periodic increases in caries prevalence had been small in comparison to the 1000 AD increase, when sugar cane became more accessible to the Western world. Treatment consisted mainly of herbal remedies and charms, but sometimes also included bloodletting. The of the time provided services that included tooth extractions. Learning their training from apprenticeships, these health providers were quite successful in ending tooth pain and likely prevented systemic spread of infections in many cases. Among Roman Catholics, prayers to Saint Apollonia, the patroness of dentistry, were meant to heal pain derived from tooth infection.Elliott, Jane (October 8, 2004). Medieval teeth 'better than Baldrick's' , BBC news.
There is also evidence of caries increase when Indigenous people in North America changed from a strictly hunter-gatherer diet to a diet with maize. Rates also increased after contact with colonizing Europeans, implying an even greater dependence on maize.
During the European Age of Enlightenment, the belief that a "tooth worm" caused caries was also no longer accepted in the European medical community. Pierre Fauchard, known as the father of modern dentistry, was one of the first to reject the idea that worms caused tooth decay and noted that sugar was detrimental to the teeth and gingiva.McCauley, H. Berton. Pierre Fauchard (1678–1761) , hosted on the Pierre Fauchard Academy website. The excerpt comes from a speech given at a Maryland PFA Meeting on March 13, 2001. Page accessed January 17, 2007. In 1850, another sharp increase in the prevalence of caries occurred and is believed to be a result of widespread diet changes. Prior to this time, cervical caries was the most frequent type of caries. The increased availability of sugar cane, refined flour, bread, and sweetened tea corresponded with a greater number of pit and fissure caries.
In the 1890s, W. D. Miller conducted a series of studies that led him to propose an explanation for dental caries that was influential for current theories. He found that bacteria inhabited the mouth and that they produced acids that dissolved tooth structures when in the presence of fermentable carbohydrates. This explanation is known as the chemoparasitic caries theory. Miller's contribution, along with the research on plaque by G. V. Black and J. L. Williams, served as the foundation for the current explanation of the etiology of caries. Several of the specific strains of lactobacilli were identified in 1921 by Fernando E. Rodríguez Vargas.
In 1924 in London, Killian Clarke described a spherical bacterium in chains isolated from carious lesions which he called Streptococcus mutans. Although Clarke proposed that this organism was the cause of caries, the discovery was not followed up. Later, in 1954 in the US, Frank Orland working with hamsters showed that caries was transmissible and caused by acid-producing Streptococcus thus ending the debate whether dental caries were resultant from bacteria. It was not until the late 1960s that it became generally accepted that the Streptococcus isolated from hamster caries was the same as S. mutans.
Tooth decay has been present throughout human history, from early hominids millions of years ago, to modern humans. The prevalence of caries increased dramatically in the 19th century, as the Industrial Revolution made certain items, such as refined sugar and flour, readily available. The diet of the "newly industrialized English working class" then became centered on bread, jam, and sweetened tea, greatly increasing both sugar consumption and caries.
Cariesology or cariology is the study of dental caries.
Signs and symptoms
A person experiencing caries may not be aware of the disease. Health Promotion Board: Dental Caries , affiliated with the Singapore government. Page accessed August 14, 2006. The earliest sign of a new carious lesion is the appearance of a chalky white spot on the surface of the tooth, indicating an area of demineralization of enamel. This is referred to as a white spot lesion, an incipient carious lesion, or a "micro-cavity".
Cause
Four things are required for caries to form: a tooth surface (enamel or dentin), caries-causing bacteria, fermentable (such as sucrose), and time. (1993). 9780192622143, Oxford Univ. Press. ISBN 9780192622143 This involves Adhesion of food to the teeth and acid creation by the bacteria that makes up the dental plaque. However, these four criteria are not always enough to cause the disease and a sheltered environment promoting development of a cariogenic biofilm is required. The caries disease process does not have an inevitable outcome, and different individuals will be susceptible to different degrees depending on the shape of their teeth, oral hygiene habits, and the buffering capacity of their saliva. Dental caries can occur on any surface of a tooth that is exposed to the oral cavity, but not the structures that are retained within the bone. (1990). 9780192618085, Oxford University Press. ISBN 9780192618085
(2025). 9780128186190, Elsevier. ISBN 9780128186190
Bacteria
The most common bacteria associated with dental cavities are the mutans streptococci, most prominently Streptococcus mutans and Streptococcus sobrinus, and Lactobacillus. However, cariogenic bacteria (the ones that can cause the disease) are present in dental plaque. They are usually in concentrations too low to cause problems unless there is a shift in the balance. Alt URL This is driven by local environmental change, such as frequent sugar intake or inadequate biofilm removal (toothbrushing). If left untreated, the disease can lead to pain, tooth loss and infection. Cavities/tooth decay , hosted on the Mayo Clinic website. Page accessed May 25, 2008.
Dietary sugars
Bacteria in a person's mouth convert glucose, fructose, and most commonly sucrose (table sugar) into acids, mainly lactic acid, through a glycolytic process called fermentation. If left in contact with the tooth, these acids may cause demineralization, which is the dissolution of its mineral content. The process is dynamic, however, as remineralization can also occur if the acid is neutralized by saliva or mouthwash. Fluoride toothpaste or dental varnish may aid remineralization. If demineralization continues over time, enough mineral content may be lost so that the soft organic compound material left behind disintegrates, forming a cavity or hole. The impact such sugars have on the progress of dental caries is called cariogenicity. Sucrose, although a bound glucose and fructose unit, is more cariogenic than a mixture of equal parts of glucose and fructose. This is due to the bacteria using the energy in the saccharide bond between the glucose and fructose subunits. S.mutans adheres to the biofilm on the tooth by converting sucrose into an extremely adhesive substance called dextran polysaccharide by the enzyme dextran sucranase.Madigan M.T. & Martinko J.M. Brock – Biology of Microorganisms. 11th Ed., 2006, Pearson, USA. pp. 705
Exposure
The frequency with which teeth are exposed to cariogenic (acidic) environments affects the likelihood of caries development. After meals or snack food, the bacteria in the mouth Metabolism sugar, resulting in an acidic by-product that decreases pH. As time progresses, the pH returns to normal due to the buffering capacity of saliva and the dissolved mineral content of tooth surfaces. During every exposure to the acidic environment, portions of the inorganic mineral content at the surface of teeth dissolve and can remain dissolved for two hours. Dental Caries , hosted on the University of California, Los Angeles School of Dentistry website. Page accessed August 14, 2006. Since teeth are vulnerable during these acidic periods, the development of dental caries relies heavily on the frequency of acid exposure.
Teeth
Certain diseases and disorders that affect the teeth may increase an individual's risk for cavities.
Other factors
A reduced salivary flow rate is associated with increased caries since the buffering capability of saliva is not present to counterbalance the acidic environment created by certain foods. As a result, medical conditions that reduce the amount of saliva produced by , in particular the submandibular gland and parotid gland, are likely to lead to xerostomia and thus to widespread tooth decay. Examples include Sjögren syndrome, diabetes mellitus, diabetes insipidus, and sarcoidosis.Neville, B. W., Douglas Damm, Carl Allen, Jerry Bouquot. Oral & Maxillofacial Pathology 2nd edition, 2002, p. 398. . Medications, such as antihistamines and antidepressants, can also impair salivary flow.
Pathophysiology
Teeth are bathed in saliva and have a coating of bacteria on them (biofilm) that continually forms. The development of biofilm begins with Dental pellicle formation. Pellicle is an acellular proteinaceous film that covers the teeth. Bacteria colonize on the teeth by adhering to the pellicle-coated surface. Over time, a mature biofilm is formed, creating a cariogenic environment on the tooth surface.
Enamel
Tooth enamel is a highly mineralized acellular tissue, and caries act upon it through a chemical process brought on by the acidic environment produced by bacteria. As the bacteria consume the sugar and use it for their own energy, they produce lactic acid. The effects of this process include the demineralization of crystals in the enamel, caused by acids, over time, until the bacteria physically penetrate the dentin. , which are the basic unit of the enamel structure, run perpendicularly from the surface of the tooth to the dentin. Since demineralization of enamel by caries follows the direction of the enamel rods, the different triangular patterns between pit and fissure and smooth-surface caries develop in the enamel because the orientation of enamel rods are different in the two areas of the tooth.
Dentin
Unlike enamel, the dentin reacts to the progression of dental caries. After tooth formation, the , which produce enamel, are destroyed once amelogenesis is complete and thus cannot later regenerate enamel after its destruction. On the other hand, dentin is dentinogenesis continuously throughout life by , which reside at the border between the pulp and dentin. Since odontoblasts are present, a stimulus, such as caries, can trigger a biological response. These defense mechanisms include the formation of sclerotic and tertiary dentin." Teeth & Jaws: Caries, Pulp, & Periapical Conditions ," hosted on the University of Southern California School of Dentistry website. Page accessed June 22, 2007.
Sclerotic dentin
The structure of dentin is an arrangement of microscopic channels, called dentinal tubules, which radiate outward from the pulp chamber to the exterior cementum or enamel border.Ross, Michael H., Kaye, Gordon I. and Pawlina, Wojciech (2003) Histology: a text and atlas. 4th edition, p. 450. . The diameter of the dentinal tubules is largest near the pulp (about 2.5 μm) and smallest (about 900 nm) at the junction of dentin and enamel.Nanci, p. 166 The carious process continues through the dentinal tubules, which are responsible for the triangular patterns resulting from the progression of caries deep into the tooth. The tubules also allow caries to progress faster.
Tertiary dentin
In response to dental caries, there may be production of more dentin in the direction of the pulp. This new dentin is referred to as tertiary dentin. Tertiary dentin is produced to protect the pulp for as long as possible from the advancing bacteria. As more tertiary dentin is produced, the size of the pulp decreases. This type of dentin has been subdivided according to the presence or absence of the original odontoblasts. If the odontoblasts survive long enough to react to the dental caries, then the dentin produced is called "reactionary" dentin. If the odontoblasts are killed, the dentin produced is known as "reparative" dentin.
Cementum
The incidence of cemental caries increases in older adults as gingival recession occurs from either trauma or periodontal disease. It is a chronic condition that forms a large, shallow lesion and slowly invades first the root's cementum and then dentin to cause a chronic infection of the pulp (see further discussion under classification by affected hard tissue). Because dental pain is a late finding, many lesions are not detected early, resulting in restorative challenges and increased tooth loss.Fehrenbach, MJ and Popowics, T (2026). Illustrated Dental Embryology, Histology, and Anatomy, 6th edition. Elsevier, p. 194.
Diagnosis
The presentation of caries is highly variable. However, the risk factors and stages of development are similar. Initially, it may appear as a small chalky area (smooth surface caries), which may eventually develop into a large cavitation. Sometimes caries may be directly visible. However, other methods of detection, such as radiography, are used for less visible areas of teeth and to judge the extent of destruction. Lasers for detecting caries allow detection without ionizing radiation and are now used for the detection of interproximal decay (between the teeth).
(2015). 9781118935828, John Wiley & Sons. ISBN 9781118935828
Classification
Caries can be classified by location, etiology, rate of progression, and affected hard tissues. These forms of classification can be used to characterize a particular case of tooth decay to more accurately represent the condition to others and also indicate the severity of tooth destruction. In some instances, caries is described in other ways that might indicate the cause. The G. V. Black classification is as follows:
Early childhood caries
Early childhood caries (ECC), also known as "baby bottle caries," "baby bottle tooth decay" or "bottle rot," is a pattern of decay found in young children with their deciduous teeth (baby) teeth. This must include the presence of at least one carious lesion on a primary tooth in a child under the age of 6 years.Sukumaran Anil. Early Childhood Caries: Prevalence, Risk Factors, and Prevention The teeth most likely affected are the maxillary anterior teeth, but all teeth can be affected. ADA Early Childhood Tooth Decay (Baby Bottle Tooth Decay) . Hosted on the American Dental Association website. Page accessed August 14, 2006. The name for this type of caries comes from the fact that the decay usually is a result of allowing children to fall asleep with sweetened liquids in their bottles or feeding children sweetened liquids multiple times during the day.Statement on Early Childhood Caries, American Dental Association at
(2010). 9781905829088, Scottish Dental Clinical Effectiveness Programme. ISBN 9781905829088
Rate of progression
Temporal descriptions can be applied to caries to indicate the progression rate and previous history. "Acute" signifies a quickly developing condition, whereas "chronic" describes a condition that has taken an extended time to develop, in which thousands of meals and snacks, many causing some acid demineralization that is not remineralized, eventually result in cavities.
Affected hard tissue
Depending on which hard tissues are affected, it is possible to describe caries as involving enamel, dentin, or cementum. Early in its development, caries may affect only enamel. Once the extent of decay reaches the deeper layer of dentin, the term "dentinal caries" is used. Since cementum is the hard tissue that covers the roots of teeth, it is not often affected by decay unless the roots of teeth are exposed to the mouth. Although the term "cementum caries" may be used to describe the decay on the roots of teeth, very rarely does caries affect the cementum alone.
Prevention
Oral hygiene
The primary approach to dental hygiene care consists of tooth-brushing and dental floss. The purpose of oral hygiene is to remove and prevent the formation of dental plaque or dental biofilm, Introduction to Dental Plaque . Hosted on the Leeds Dental Institute Website. Page accessed August 14, 2006. although studies have shown this effect on caries is limited. While there is no evidence that flossing prevents tooth decay, the practice is still generally recommended.
Dietary modification
People who eat more get more cavities, with cavities increasing exponentially with increasing sugar intake. Populations with less sugar intake have fewer cavities. In one population, in Nigeria, where sugar consumption was about 2g/day, only two percent of the population, of any age, had had a cavity.
Other measures
The use of is a means of prevention. A sealant is a thin plastic-like coating applied to the chewing surfaces of the molars to prevent food from being trapped inside pits and fissures. This deprives resident plaque bacteria of carbohydrate, preventing the formation of pit and fissure caries. Sealants are usually applied to the teeth of children as soon as the teeth erupt, but adults are also receiving them if not previously performed. Sealants can wear out and fail to prevent access of food and plaque bacteria inside pits and fissures, and must be replaced. Therefore, they must be checked regularly by dental professionals. Dental sealants are more effective at preventing occlusal decay compared to fluoride varnish applications.
Treatment
No treatment No treatment Non-operative treatment Operative treatment No replacement No replacement Repair or replacement of filling No treatment Non-operative treatment Repair or replacement of filling (2025). 9781405107181, Blackwell Munksgaard. ISBN 9781405107181
Epidemiology
for dental caries per 100,000 inhabitants in 2004:
History
There is a long history of dental caries. Over a million years ago, such as Paranthropus had cavities. The largest increases in the prevalence of caries have been associated with dietary changes. Epidemiology of Dental Disease , hosted on the University of Illinois at Chicago website. Page accessed January 9, 2007.
Etymology and usage
Naturalized from Latin into English (a loanword), caries in its English form originated as a mass noun that means 'rottenness', that is, 'decay'. The word is an uncountable noun.
Society and culture
It is estimated that untreated dental caries results in worldwide productivity losses in the size of about US$27 billion yearly.
Other animals
Dental caries are uncommon among companion animals.
See also
General and cited sources
External links
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